Overview of vaccines and immunisation.

نویسندگان

  • Myron M Levine
  • James D Campbell
  • Karen L Kotloff
چکیده

During the past two decades, advances in biotechnology and increased knowledge of the inductive and effector components of immune responses have revolutionized the field of vaccine development. This has opened a vaccine ‘pipeline’ that has already resulted in the licensure of many new and improved vaccines including recombinant hepatitis B vaccine, acellular pertussis vaccines, and conjugate vaccines against Haemophilus influenzae type b, group C Neisseria meningitidis and Streptococcus pneumoniae. The application of recombinant DNA technology, polymerase chain reaction amplification, monoclonal antibodies, peptide synthesis, genomics (in particular, the sequencing of the entire genome of various pathogens1), proteomics and high throughput informatics are examples of the powerful tools driving the development of desirable new and improved vaccines2. Combined with advances in adjuvant technology, specific methods of modulating immune responses (e.g. by the administration of various cytokines), and novel ways of delivering antigens, many interesting new vaccine candidates and technologies are reaching the stage of clinical testing.

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عنوان ژورنال:
  • British medical bulletin

دوره 62  شماره 

صفحات  -

تاریخ انتشار 2002